Apoptosis is a biological process crucial for the development and maintenance of healthy living organism. A deregulated apoptosis underlies many diseases, including cancer. Under hypoxic conditions, p53 starts to accumulate and competes with HIF-1 for their common binding target p300. This can lead to the repression of HIF-1, and trigger the apoptotic derive. In addition apoptosis is accompanied by an enhancement of potassium (K+) fluxes, which in turn create a low-potassium intracellular micro-environment, which cooperates to the activation of caspases, the final actors of the apoptotic cascade. Based on this scenario, we elaborate a dynamical model aimed at resolving the complex dynamical interplay between the aforementioned processes. In the ideal continuum limit, the model reduces to a system of coupled differential equations, whose dynamics is analytically inspected.

A dynamical model of apoptosis and its role in tumor progression / Pasquale Laise; Duccio Fanelli; Annarosa Arcangeli. - In: COMMUNICATIONS IN NONLINEAR SCIENCE & NUMERICAL SIMULATION. - ISSN 1007-5704. - STAMPA. - 17:(2011), pp. 1795-1804. [10.1016/j.cnsns.2011.09.014]

A dynamical model of apoptosis and its role in tumor progression

ARCANGELI, ANNAROSA
2011

Abstract

Apoptosis is a biological process crucial for the development and maintenance of healthy living organism. A deregulated apoptosis underlies many diseases, including cancer. Under hypoxic conditions, p53 starts to accumulate and competes with HIF-1 for their common binding target p300. This can lead to the repression of HIF-1, and trigger the apoptotic derive. In addition apoptosis is accompanied by an enhancement of potassium (K+) fluxes, which in turn create a low-potassium intracellular micro-environment, which cooperates to the activation of caspases, the final actors of the apoptotic cascade. Based on this scenario, we elaborate a dynamical model aimed at resolving the complex dynamical interplay between the aforementioned processes. In the ideal continuum limit, the model reduces to a system of coupled differential equations, whose dynamics is analytically inspected.
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1795
1804
Pasquale Laise; Duccio Fanelli; Annarosa Arcangeli
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2158/657215
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