Regional cerebral blood flow was studied using 99mTc-HM-PAO and single photon emission computed tomography (SPECT) in five healthy subjects and in eight patients with clinical and computed tomography (CT) features of subcortical arteriosclerotic encephalopathy. All the patients and controls underwent magnetic resonance imaging (MRI). Circumscribed cortical hypoperfusion was observed in three patients, and in one case there was no evidence of cortical or sulcal alterations on MRI. In all the patients, a reduction of the white matter perfusion was found in periventricular and/or supraventricular regions. This pattern was substantially correlated with the typical white matter hyperintensities shown by MRI scans. These findings support the hypothesis that white matter hypoperfusion is the most prominent functional abnormality in subcortical arteriosclerotic encephalopathy.

Am J Physiol Imaging. 1990;5(2):68-74.Subcortical arteriosclerotic encephalopathy: single photon emission computed tomography-magnetic resonance imaging correlation / De Cristofaro MT; Mascalchi M; Pupi A; Nencini P; Formiconi AR; Inzitari D; Dal Pozzo G; Meldolesi U.. - In: AMERICAN JOURNAL OF PHYSIOLOGIC IMAGING. - ISSN 0885-8276. - STAMPA. - (1990), pp. 68-74.

Am J Physiol Imaging. 1990;5(2):68-74.Subcortical arteriosclerotic encephalopathy: single photon emission computed tomography-magnetic resonance imaging correlation.

MASCALCHI, MARIO;PUPI, ALBERTO;FORMICONI, ANDREAS ROBERT;INZITARI, DOMENICO;DAL POZZO, GIANCARLO;MELDOLESI, UGO
1990

Abstract

Regional cerebral blood flow was studied using 99mTc-HM-PAO and single photon emission computed tomography (SPECT) in five healthy subjects and in eight patients with clinical and computed tomography (CT) features of subcortical arteriosclerotic encephalopathy. All the patients and controls underwent magnetic resonance imaging (MRI). Circumscribed cortical hypoperfusion was observed in three patients, and in one case there was no evidence of cortical or sulcal alterations on MRI. In all the patients, a reduction of the white matter perfusion was found in periventricular and/or supraventricular regions. This pattern was substantially correlated with the typical white matter hyperintensities shown by MRI scans. These findings support the hypothesis that white matter hypoperfusion is the most prominent functional abnormality in subcortical arteriosclerotic encephalopathy.
1990
68
74
De Cristofaro MT; Mascalchi M; Pupi A; Nencini P; Formiconi AR; Inzitari D; Dal Pozzo G; Meldolesi U.
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/687726
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