The interactions of ketoprofen and ibuprofen with some randomly alkylated beta-cyclodextrins were investigated both in aqueous solution (phase-solubility analysis) and in the solid state (by differential scanning calorimetry and X-ray diffractometry. It was observed that the molecular features of the guest played a role in such interactions, which were particularly strong in the case of methyl-betacyclodextrin.
COMPARATIVE STUDY OF THE INCLUSION PROPERTIES OF BETA-CYCLODEXTRINS FOR KETOPROFEN AND IBUPROFEN IN SOLUTION AND IN THE SOLID STATE / P. Mura; G.P. Bettinetti; A. Manderioli; M.T. Faucci; G. Bramanti; M. Setti. - STAMPA. - (1996), pp. 325-328. (Intervento presentato al convegno 8TH INTERNATIONAL SYMPOSIUM ON CYCLODEXTRINS tenutosi a Budapest nel March 31-April 2 1996).
COMPARATIVE STUDY OF THE INCLUSION PROPERTIES OF BETA-CYCLODEXTRINS FOR KETOPROFEN AND IBUPROFEN IN SOLUTION AND IN THE SOLID STATE
MURA, PAOLA ANGELA;BETTINETTI, GIAMPIERO;BRAMANTI, GIAMPIERO;
1996
Abstract
The interactions of ketoprofen and ibuprofen with some randomly alkylated beta-cyclodextrins were investigated both in aqueous solution (phase-solubility analysis) and in the solid state (by differential scanning calorimetry and X-ray diffractometry. It was observed that the molecular features of the guest played a role in such interactions, which were particularly strong in the case of methyl-betacyclodextrin.
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