Dissolution rate enhancements of naproxen (NAP) in mixtures with amorphous (DS 1.8 randomly methylated) or crystalline (2,6-di-O-methyl) betaCdyclodextrin were directly and linearly related to the carrier-to-drug ratios. Substantially the same increase in dissolution efficiency (4.5- to 19-times that of pure NAP) was carried out by both carriers in powder mixtures, while the crystalline carrier was a better dissolution-rate enhancer from non-disintegrating tablets at constant surface area. Differential scanning calorimetry showed a similar heating-induced modification of the solid state of NAP brought about by carriers.
DISSOLUTION RATE AND THERMAL PROPERTIES OF NAPROXEN IN MIXTURES WITH AMORPHOUS OR CRYSTALLLINE DIMETHYL-BETACYCLODEXTRIN / G. P. Bettinetti; M. Sorrenti; A. Negri; P. Mura; M. T. Faucci. - STAMPA. - (1998), pp. 371-374. (Intervento presentato al convegno 9TH INTERNATIONAL SYMPOSIUM ON CYCLODEXTRINS tenutosi a SANTIAGO DE COMPOSTELA nel 31/05 - 3/06/1998).
DISSOLUTION RATE AND THERMAL PROPERTIES OF NAPROXEN IN MIXTURES WITH AMORPHOUS OR CRYSTALLLINE DIMETHYL-BETACYCLODEXTRIN
BETTINETTI, GIAMPIERO;MURA, PAOLA ANGELA;
1998
Abstract
Dissolution rate enhancements of naproxen (NAP) in mixtures with amorphous (DS 1.8 randomly methylated) or crystalline (2,6-di-O-methyl) betaCdyclodextrin were directly and linearly related to the carrier-to-drug ratios. Substantially the same increase in dissolution efficiency (4.5- to 19-times that of pure NAP) was carried out by both carriers in powder mixtures, while the crystalline carrier was a better dissolution-rate enhancer from non-disintegrating tablets at constant surface area. Differential scanning calorimetry showed a similar heating-induced modification of the solid state of NAP brought about by carriers.
I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
