PHASE-SOLUBILITY ANAIYSIS AND MOLECULAR MODELLING IN THE STUDY OF INTERACTION OF NAPROXEN WITH HYDROXYETHYL-ß-CYCIODEXTRINS

Melani, Fabrizio; Mura, Paola Angela; Bettinetti, G.; Giordano, F.

The solubilizing ability towards naproxen of amorphous hydroxyethyl-beta cyclodextrins with different degrees of substitution (MS 0.6, 1.0 and 1.6) was tested and compared with that of crystalline native beta-cyclodextrin. Computer aided molecular modeling was also used in the study of naproxen-cyclodextrin inclusion complexation.

trova@unifi

Titolo:	PHASE-SOLUBILITY ANAIYSIS AND MOLECULAR MODELLING IN THE STUDY OF INTERACTION OF NAPROXEN WITH HYDROXYETHYL-ß-CYCIODEXTRINS
Autori di Ateneo:	MELANI, FABRIZIO MURA, PAOLA ANGELA G. BETTINETTI F. GIORDANO mostra contributor esterni nascondi contributor esterni
Autori:	MELANI, FABRIZIO; MURA, PAOLA ANGELA; G. BETTINETTI; F. GIORDANO
Anno di registrazione:	1994
Titolo del libro:	7th International Cyclodextrin Symposium
Titolo del congresso:	7th INTERNATIONAL CYCLODEXTRÍN SYMPOSIUM
Luogo del congresso:	Tokyo
Data del congresso:	25-28 aprile 1994
Abstract:	The solubilizing ability towards naproxen of amorphous hydroxyethyl-beta cyclodextrins with different degrees of substitution (MS 0.6, 1.0 and 1.6) was tested and compared with that of crystalline native beta-cyclodextrin. Computer aided molecular modeling was also used in the study of naproxen-cyclodextrin inclusion complexation.
Handle:	http://hdl.handle.net/2158/7010
Appare nelle tipologie:	4a - Articolo in atti di congresso

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