Short term memory involves alterations in the effectiveness of pre-existing synaptic connections via covalent modifications of proteins while long term memory requires protein synthesis at dendritic level. Acetylcholine plays a crucial role in attention but its role in memory is still not elucidated. Aim of our research was to investigate the role of cholinergic neurotransmission on mammalian target of rapamycin (mTOR) and p70S6 kinase (p70S6K) activation in the hippocampus during the formation of short and long term memory. Our data support the idea that the cholinergic system is involved in short term but not long term memory encoding and demonstrate that mTOR and p70S6K activation are implicated in long term memory formation. These results support the hypothesis that distinct molecular mechanisms underlie the two different forms of memory.
A study upon short term and long term memory mechanisms / Lana, D; Cerbai, F; Petkova-Kirova, P; Giannetti, A; Maraula, G; Pugliese, AM; Giovannini, MG. - ELETTRONICO. - (2012), pp. 251-253. (Intervento presentato al convegno 6th European Congress of Pharmacology tenutosi a Granada (Spain) nel July 17th-20th, 2012).
A study upon short term and long term memory mechanisms
LANA, DANIELE;PUGLIESE, ANNA MARIA;GIOVANNINI, MARIA GRAZIA
2012
Abstract
Short term memory involves alterations in the effectiveness of pre-existing synaptic connections via covalent modifications of proteins while long term memory requires protein synthesis at dendritic level. Acetylcholine plays a crucial role in attention but its role in memory is still not elucidated. Aim of our research was to investigate the role of cholinergic neurotransmission on mammalian target of rapamycin (mTOR) and p70S6 kinase (p70S6K) activation in the hippocampus during the formation of short and long term memory. Our data support the idea that the cholinergic system is involved in short term but not long term memory encoding and demonstrate that mTOR and p70S6K activation are implicated in long term memory formation. These results support the hypothesis that distinct molecular mechanisms underlie the two different forms of memory.File | Dimensione | Formato | |
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