our data indicate an essential role of the HH-GLI1 signaling in controlling self-renewal and tumor initiation of melanoma CSC/TIC. Targeting HH-GLI1 is thus predicted to reduce the melanoma stem cell compartment.
HEDGEHOG-GLI Signaling Drives Self-Renewal and Tumorigenicity of Human Melanoma-Initiating Cells / Santini R;Vinci MC;Pandolfi S;Penachioni JY;Montagnani V;Olivito B;Gattai R;Pimpinelli N;Gerlini G;Borgognoni L;Stecca B. - In: STEM CELLS. - ISSN 1066-5099. - STAMPA. - 30:(2012), pp. 1808-1818. [10.1002/stem.1160]
HEDGEHOG-GLI Signaling Drives Self-Renewal and Tumorigenicity of Human Melanoma-Initiating Cells.
MONTAGNANI, VALENTINA;GATTAI, RICCARDO;PIMPINELLI, NICOLA;
2012
Abstract
our data indicate an essential role of the HH-GLI1 signaling in controlling self-renewal and tumor initiation of melanoma CSC/TIC. Targeting HH-GLI1 is thus predicted to reduce the melanoma stem cell compartment.
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