THE CAUDAL VENTRAL RESPIRATORY GROUP IS A SITE OF ACTION OF ANTITUSSIVE DRUGS IN THE RABBIT Abstract number: P68 MUTOLO D, BONGIANNI F, CINELLI E, PANTALEO T 1Dip. Scienze Fisiologiche, Univ. di Firenze, Italy We have previously shown that the caudal nucleus tractus solitarii is a site of action of some antitussive drugs and that the caudal ventral respiratory group (cVRG) has a crucial role in determining the cough motor pattern. These findings led us to suggest that the cVRG may also be a site of action of antitussive drugs. To address this issue, we investigated changes in baseline respiratory activity and cough responses to tracheobronchial mechanical stimulation following microinjections (30–50 nl) of some antitussive drugs into the cVRG of pentobarbitone anesthetized, spontaneously breathing rabbits. DAMGO and baclofen at the lower concentrations (0.5 and 0.1 mM, respectively) decreased cough number, peak abdominal activity, peak tracheal pressure, and increased cough-related total cycle duration (TT). At the higher concentrations (5 and 1 mM, respectively), both drugs abolished the cough reflex. They also affected baseline respiratory activity. Both drugs reduced peak abdominal activity, while only DAMGO increased TT. The neurokinin-1 (NK1) receptor antagonist CP-99,994 (10 mM) decreased cough number, peak abdominal activity and peak tracheal pressure, without affecting baseline respiration. The NK2 receptor antagonist MEN 10376 (5 mM) had no effect. The results suggest that several neural substrates involved in cough regulation may be sites of action of antitussive agents.

The caudal ventral respiratory group is a site of action of antitussive drugs in the rabbit / Mutolo D.; Bongianni F.; Cinelli E.; Pantaleo T.. - In: ACTA PHYSIOLOGICA. - ISSN 1748-1708. - STAMPA. - 200 (suppl. 681):(2010), pp. 68-68. (Intervento presentato al convegno 61st National Congress of the Italian Physiological Society 9/15/2010-9/17/2010 Varese, Italy tenutosi a Varese, Italy nel 15-17 Settembre, 2010).

The caudal ventral respiratory group is a site of action of antitussive drugs in the rabbit

MUTOLO, DONATELLA;BONGIANNI, FULVIA;CINELLI, ELENIA;PANTALEO, TITO
2010

Abstract

THE CAUDAL VENTRAL RESPIRATORY GROUP IS A SITE OF ACTION OF ANTITUSSIVE DRUGS IN THE RABBIT Abstract number: P68 MUTOLO D, BONGIANNI F, CINELLI E, PANTALEO T 1Dip. Scienze Fisiologiche, Univ. di Firenze, Italy We have previously shown that the caudal nucleus tractus solitarii is a site of action of some antitussive drugs and that the caudal ventral respiratory group (cVRG) has a crucial role in determining the cough motor pattern. These findings led us to suggest that the cVRG may also be a site of action of antitussive drugs. To address this issue, we investigated changes in baseline respiratory activity and cough responses to tracheobronchial mechanical stimulation following microinjections (30–50 nl) of some antitussive drugs into the cVRG of pentobarbitone anesthetized, spontaneously breathing rabbits. DAMGO and baclofen at the lower concentrations (0.5 and 0.1 mM, respectively) decreased cough number, peak abdominal activity, peak tracheal pressure, and increased cough-related total cycle duration (TT). At the higher concentrations (5 and 1 mM, respectively), both drugs abolished the cough reflex. They also affected baseline respiratory activity. Both drugs reduced peak abdominal activity, while only DAMGO increased TT. The neurokinin-1 (NK1) receptor antagonist CP-99,994 (10 mM) decreased cough number, peak abdominal activity and peak tracheal pressure, without affecting baseline respiration. The NK2 receptor antagonist MEN 10376 (5 mM) had no effect. The results suggest that several neural substrates involved in cough regulation may be sites of action of antitussive agents.
2010
Acta Physiologica 2010; Volume 200, Supplement 681 Abstracts of the 61st National Congress of the Italian Physiological Society 9/15/2010-9/17/2010 Varese, Italy
61st National Congress of the Italian Physiological Society 9/15/2010-9/17/2010 Varese, Italy
Varese, Italy
Mutolo D.; Bongianni F.; Cinelli E.; Pantaleo T.
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/773144
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