Head-to-tail histidine containing cyclopeptides can be efficiently synthesised by a three-dimensional orthogonal solid-phase strategy (Fmoc/tBu/allyl) v/a anchoring the imidazole ring to trityi-resins. Furthermore, Fmoc-His(Trt-®)-OAl can be a useful starting support for the preparation of diketopiperazine combinatorial libraries.
Cyclisation of Histidine Containing Peptides in the Solid-Phase by Anchoring the Imidazole ring to Trityl Resins / G. SABATINO; M. CHELLI; S. MAZZUCCO; M. GINANNESCHI; A.M. PAPINI. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - STAMPA. - 40(4):(1999), pp. 809-812.
Cyclisation of Histidine Containing Peptides in the Solid-Phase by Anchoring the Imidazole ring to Trityl Resins
SABATINO, GIUSEPPINA;M. GINANNESCHI;PAPINI, ANNA MARIA
1999
Abstract
Head-to-tail histidine containing cyclopeptides can be efficiently synthesised by a three-dimensional orthogonal solid-phase strategy (Fmoc/tBu/allyl) v/a anchoring the imidazole ring to trityi-resins. Furthermore, Fmoc-His(Trt-®)-OAl can be a useful starting support for the preparation of diketopiperazine combinatorial libraries.
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