Aqueous mixtures of formaldehyde and glutathione react to form a variety of cyclized adducts in addition to S-hydroxymethylglutathione. The adducts are in labile equilibrium with each other and are not readily separated. The structures of two of the other major adducts were determined by concerted application of '3C-'H two-dimensional chemical-shift correlation, fast-atom-bombardment mass spectrometry and tandem mass spectrometry to the adduct mixtures in aqueous solution.
FORMALDEHYDE ADDUCTS OF GLUTATHIONE - STRUCTURE ELUCIDATION BY TWO-DIMENSIONAL NMR-SPECTROSCOPY AND FAST-ATOM-BOMBARDMENT TANDEM MASS-SPECTROMETRY / NAYLOR S; MASON RP; SANDERS JKM; WILLIAMS DH; MONETI G. - In: BIOCHEMICAL JOURNAL. - ISSN 0264-6021. - STAMPA. - 249:(1988), pp. 573-579.
FORMALDEHYDE ADDUCTS OF GLUTATHIONE - STRUCTURE ELUCIDATION BY TWO-DIMENSIONAL NMR-SPECTROSCOPY AND FAST-ATOM-BOMBARDMENT TANDEM MASS-SPECTROMETRY
MONETI, GLORIANO
1988
Abstract
Aqueous mixtures of formaldehyde and glutathione react to form a variety of cyclized adducts in addition to S-hydroxymethylglutathione. The adducts are in labile equilibrium with each other and are not readily separated. The structures of two of the other major adducts were determined by concerted application of '3C-'H two-dimensional chemical-shift correlation, fast-atom-bombardment mass spectrometry and tandem mass spectrometry to the adduct mixtures in aqueous solution.
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