Current evidence indicates an inverse association between Helicobacter pylori and asthma and allergy. H. pylori is a Gram-negative bacterium which represents the major cause of peptic ulcer and gastric cancer, and preferentially elicits a T helper (Th)-1 response. Many H. pylori factors, such as the neutrophil-activating factor of H. pylori (HP-NAP), are able to drive Th-1 polarization and to display a powerful inhibition of allergic Th-2 response. This article proposes an overview of the actual knowledge about the effects of H. pylori on asthma and allergy. Special attention has been drawn to HP-NAP as a potential novel strategy for the prevention and treatment of asthma and atopy.

The effect of Helicobacter pylori on asthma and allergy / A. Amedei; G. Codolo; G. Del Prete; M. de Bernard; M.M. D’Elios. - In: JOURNAL OF ASTHMA AND ALLERGY. - ISSN 1178-6965. - ELETTRONICO. - (2010), pp. 139-147. [10.2147/JAA.S8971]

The effect of Helicobacter pylori on asthma and allergy

AMEDEI, AMEDEO;DEL PRETE, GIANFRANCO;D'ELIOS, MARIO MILCO
2010

Abstract

Current evidence indicates an inverse association between Helicobacter pylori and asthma and allergy. H. pylori is a Gram-negative bacterium which represents the major cause of peptic ulcer and gastric cancer, and preferentially elicits a T helper (Th)-1 response. Many H. pylori factors, such as the neutrophil-activating factor of H. pylori (HP-NAP), are able to drive Th-1 polarization and to display a powerful inhibition of allergic Th-2 response. This article proposes an overview of the actual knowledge about the effects of H. pylori on asthma and allergy. Special attention has been drawn to HP-NAP as a potential novel strategy for the prevention and treatment of asthma and atopy.
2010
139
147
A. Amedei; G. Codolo; G. Del Prete; M. de Bernard; M.M. D’Elios
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/776620
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