Data indicate that both CD8+ and CD4+ T cells, Th1/Th17, but not Th2, T cells can help TF production. Both cell-to-cell contact with activated T cells, Th1-type and Th17 cytokines, in particular IFN-gamma and IL-17, are crucial for optimal TF synthesis, whereas Th2-derived cytokines (IL-4,IL-13, and IL-10) are inhibitory.
T cells, tissue factor and malignancy / M.M. D'Elios; M Benagiano; A Amedei; C della Bella; E Niccolai; D Prisco. - In: THROMBOSIS RESEARCH. - ISSN 0049-3848. - ELETTRONICO. - (2012), pp. 168-168.
T cells, tissue factor and malignancy
D'ELIOS, MARIO MILCO;BENAGIANO, MARISA;AMEDEI, AMEDEO;DELLA BELLA, CHIARA;NICCOLAI, ELENA;PRISCO, DOMENICO
2012
Abstract
Data indicate that both CD8+ and CD4+ T cells, Th1/Th17, but not Th2, T cells can help TF production. Both cell-to-cell contact with activated T cells, Th1-type and Th17 cytokines, in particular IFN-gamma and IL-17, are crucial for optimal TF synthesis, whereas Th2-derived cytokines (IL-4,IL-13, and IL-10) are inhibitory.
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