We investigated the effect of an in vivo treatment with losartan on the angiotensin II (ATII) contracture elicited in phenylephrine pre-contracted aortic strips isolated from normo and hyperglycemic rats. In diabetes, ROCK1 overexpression is functionally coupled with aorta hyper-reactivity towards ATII. We provide evidence stating that losartan ameliorates vascular response to ATII reducing ROCK1activity and expression
Losartan ameliorates diabetic vascular hyper-reactivity to angiotensin II by reducing ROCK1 expression and activity / L. Raimondi; S. Franchi-Micheli; E. Cerbai; A. Mugelli; P. Failli. - In: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. - ISSN 0022-2828. - ELETTRONICO. - 42, S1:(2007), pp. 266-266.
Losartan ameliorates diabetic vascular hyper-reactivity to angiotensin II by reducing ROCK1 expression and activity
RAIMONDI, LAURA;CERBAI, ELISABETTA;MUGELLI, ALESSANDRO;FAILLI, PAOLA
2007
Abstract
We investigated the effect of an in vivo treatment with losartan on the angiotensin II (ATII) contracture elicited in phenylephrine pre-contracted aortic strips isolated from normo and hyperglycemic rats. In diabetes, ROCK1 overexpression is functionally coupled with aorta hyper-reactivity towards ATII. We provide evidence stating that losartan ameliorates vascular response to ATII reducing ROCK1activity and expression
| File | Dimensione | Formato | |
|---|---|---|---|
|
Raimondi2007.pdf
accesso aperto
Tipologia:
Altro
Licenza:
Open Access
Dimensione
50.1 kB
Formato
Adobe PDF
|
50.1 kB | Adobe PDF |
I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
