Aims of the study was to investigate the molecular mechanisms underlying the effects of resistin in human hepatic stellate cells (HSC). Preliminary data indicated that resistin up-regulates the expression of the pro-inflammatory chemoldne, MCP-1, and that inhibits HSC proliferation and migration in response to PDGF-BB. Resistin also induces a rapid and transient increase in intracellular calcium concentration. Resistin exerts pro-inflammatory actions in human HSC, by activation of a pathway requiring calcium influx and NFk-B.
Calcium-dependent activation of NF-kappa B by the adipokine resistin in hepatic stellate cells / C. Bertolani; I. Petrai; S. Aleffi; P. Failli; B. Mazzinghi; P. Romagnani; C. Orlando; S. Gelmini; R. DeFranco; M. Pinzani; M. Parola; F. Marra. - In: JOURNAL OF HEPATOLOGY. - ISSN 0168-8278. - ELETTRONICO. - 42, S2:(2005), pp. 11-11.
Calcium-dependent activation of NF-kappa B by the adipokine resistin in hepatic stellate cells
BERTOLANI, CRISTIANA;PETRAI, ILARIA;ALEFFI, SARA;FAILLI, PAOLA;ROMAGNANI, PAOLA;ORLANDO, CLAUDIO;GELMINI, STEFANIA;PINZANI, MASSIMO;MARRA, FABIO
2005
Abstract
Aims of the study was to investigate the molecular mechanisms underlying the effects of resistin in human hepatic stellate cells (HSC). Preliminary data indicated that resistin up-regulates the expression of the pro-inflammatory chemoldne, MCP-1, and that inhibits HSC proliferation and migration in response to PDGF-BB. Resistin also induces a rapid and transient increase in intracellular calcium concentration. Resistin exerts pro-inflammatory actions in human HSC, by activation of a pathway requiring calcium influx and NFk-B.
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