Gastric cancer still represents a major health problem, despite a decrease in its incidence in the last years. Due to the social impact of gastric cancer (GC), there is a need for novel biomarkers in order to stratify patients into appropriate screening, surveillance, or treatment programs. Although histopathology remains the most reliable and less expensive method, numerous efforts have been made searching for novel biomarkers. In recent years, several molecules have been identified and tested for their clinical relevance in GC management. In this paper, we will focus on a well-known GC marker, whose determination is mandatory in GC, HER2, a marker whose correlation with prognosis is still controversial (VEGF-A) and a quite novel, unconventional marker, the ether-à-go-go-related gene 1 (hERG1). All these proteins can be easily detected with immunohistochemistry, a technique widely used both in diagnostic and research laboratories that represents a link between surgical and molecular pathology, basic science, and clinical medicine.

Immunohistochemical biomarkers in gastric cancer research and management / Lastraioli E;Romoli MR;Arcangeli A. - In: INTERNATIONAL JOURNAL OF SURGICAL ONCOLOGY. - ISSN 2090-1402. - ELETTRONICO. - 2012:(2012), pp. 1-9. [10.1155/2012/868645]

Immunohistochemical biomarkers in gastric cancer research and management.

LASTRAIOLI, ELENA;ARCANGELI, ANNAROSA
2012

Abstract

Gastric cancer still represents a major health problem, despite a decrease in its incidence in the last years. Due to the social impact of gastric cancer (GC), there is a need for novel biomarkers in order to stratify patients into appropriate screening, surveillance, or treatment programs. Although histopathology remains the most reliable and less expensive method, numerous efforts have been made searching for novel biomarkers. In recent years, several molecules have been identified and tested for their clinical relevance in GC management. In this paper, we will focus on a well-known GC marker, whose determination is mandatory in GC, HER2, a marker whose correlation with prognosis is still controversial (VEGF-A) and a quite novel, unconventional marker, the ether-à-go-go-related gene 1 (hERG1). All these proteins can be easily detected with immunohistochemistry, a technique widely used both in diagnostic and research laboratories that represents a link between surgical and molecular pathology, basic science, and clinical medicine.
2012
2012
1
9
Goal 3: Good health and well-being for people
Lastraioli E;Romoli MR;Arcangeli A
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/792756
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