The use of injectable local anaesthetics for the treatment of severe postoperative pain is limited by the short duration of the painkilling effect. Pre-formulation studies were carried out for the development of an injectable microparticle formulation for controlled release of prilocaine, an amino-amide type local anaesthetic suitable for intravenous, subcutaneous and intramuscular administration
Selection of PLA-polymers for the development of injectable prilocaine controlled release microparticles: Usefulness of thrmal analysis / M. Bragagni; C. Beneitez; C. Martin; D. Hernàn Pérez de la Ossa; P. Mura; M.E. Gil-Alegre. - In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. - ISSN 0378-5173. - STAMPA. - 441:(2013), pp. 468-475. [10.1016/j.ijpharm.2012.11.007]
Selection of PLA-polymers for the development of injectable prilocaine controlled release microparticles: Usefulness of thrmal analysis
BRAGAGNI, MARCO;MURA, PAOLA ANGELA;
2013
Abstract
The use of injectable local anaesthetics for the treatment of severe postoperative pain is limited by the short duration of the painkilling effect. Pre-formulation studies were carried out for the development of an injectable microparticle formulation for controlled release of prilocaine, an amino-amide type local anaesthetic suitable for intravenous, subcutaneous and intramuscular administration
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