Prothrombotic burden in a patient with recurrent thrombotic events: might an early assessment of thrombophilia be useful in the presence of a strong family history for vascular events?

A 55-year-old man (A. Z.) was admitted to Our Cardiac Step Down Unit of the tertiary center: Careggi Hospital, for an evaluation in the presence of a history of recurrent cardiovascular events. Classical cardiovascular risk factors: Hypertension on therapy with a good control, type 2 diabetes mellitus on metformin (3 g/day) with good glycemic control (glycated hemoglobin 5.6 %), high LDL cholesterol levels on statin treatment (rosuvastatin 20 mg/day) reaching a target of LDL 42 mg/dl; low HDL levels (24 mg/dl) on treatment, overweight (BMI 27.6). With regard to family history, almost all his relatives had suffered from a cardiovascular event at a young age.