A new strategy to exploit galectin presence to target matrix metalloproteinases (MMPs) is presented. A bifunctional conjugate with lactose and an inhibitor for MMPs is able to bind MMP and Gal-3 simultaneously. This compound might allow the lectin to attract the MMP inhibitor to the tumour site and to block protumoural activities of the lectin at the same time.
Targeting Matrix Metalloproteinases: Design of a Bifunctional Inhibitor for Presentation by Tumour-Associated Galectins / Marco Bartoloni;Blanca E. Domínguez;Elisa Dragoni;Barbara Richichi;Marco Fragai;Sabine André;Hans-Joachim Gabius;Ana Ardá;Claudio Luchinat;Jesús Jiménez-Barbero;Cristina Nativi. - In: CHEMISTRY-A EUROPEAN JOURNAL. - ISSN 0947-6539. - STAMPA. - 19:(2013), pp. 1896-1902. [10.1002/chem.201203794]
Targeting Matrix Metalloproteinases: Design of a Bifunctional Inhibitor for Presentation by Tumour-Associated Galectins
DRAGONI, ELISA;RICHICHI, BARBARA;FRAGAI, MARCO;LUCHINAT, CLAUDIO;NATIVI, CRISTINA
2013
Abstract
A new strategy to exploit galectin presence to target matrix metalloproteinases (MMPs) is presented. A bifunctional conjugate with lactose and an inhibitor for MMPs is able to bind MMP and Gal-3 simultaneously. This compound might allow the lectin to attract the MMP inhibitor to the tumour site and to block protumoural activities of the lectin at the same time.
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