Aim: The aim of this work was to analyze the eight resistance–nodulation–cell division (RND) families (a group of proteins mainly involved in multidrug resistance of Gram-negative bacteria) in 26 Burkholderia genomes in order to gain knowledge regarding their presence and distribution, to obtain a platform for future experimental tests aimed to identify new molecular targets to be used in antimicrobial therapy against Burkholderia species and to refine the annotation of RND-like sequences in these genomes. Materials & methods: A total of 417 coding sequences were retrieved and analyzed using different bioinformatics tools. Results & conclusion: A complex pattern of RND presence and distribution in the different Burkholderia species was disclosed and a core of proteins represented in all 26 genomes was identified. These ‘core’ proteins might represent useful targets of new synthetic antimicrobial compounds. Furthermore, the annotation of RND-like sequences in Burkholderia was refined.

A census of RND-superfamily proteins in the Burkholderia genus / E. Perrin; M. Fondi; M.C. Papaleo; I. Maida; G. Emiliani; S. Buroni; M.R. Pasca; G. Riccardi; R. Fani. - In: FUTURE MICROBIOLOGY. - ISSN 1746-0913. - STAMPA. - 8:(2013), pp. 923-937.

A census of RND-superfamily proteins in the Burkholderia genus

PERRIN, ELENA;FONDI, MARCO;PAPALEO, MARIA CRISTIANA;MAIDA, ISABEL;EMILIANI, GIOVANNI;FANI, RENATO
2013

Abstract

Aim: The aim of this work was to analyze the eight resistance–nodulation–cell division (RND) families (a group of proteins mainly involved in multidrug resistance of Gram-negative bacteria) in 26 Burkholderia genomes in order to gain knowledge regarding their presence and distribution, to obtain a platform for future experimental tests aimed to identify new molecular targets to be used in antimicrobial therapy against Burkholderia species and to refine the annotation of RND-like sequences in these genomes. Materials & methods: A total of 417 coding sequences were retrieved and analyzed using different bioinformatics tools. Results & conclusion: A complex pattern of RND presence and distribution in the different Burkholderia species was disclosed and a core of proteins represented in all 26 genomes was identified. These ‘core’ proteins might represent useful targets of new synthetic antimicrobial compounds. Furthermore, the annotation of RND-like sequences in Burkholderia was refined.
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923
937
E. Perrin; M. Fondi; M.C. Papaleo; I. Maida; G. Emiliani; S. Buroni; M.R. Pasca; G. Riccardi; R. Fani
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2158/806082
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