Current rodent models of human depression suffer from limited construct and external validity whereby they disregard the nature-nurture interactive origin of the disease and are normally suited to inflexible conditions (e.g. single background strain). We developed a animal model reproducing several depressive-like features (symptoms) through the combination of reduced serotonin and environmental stress during the early stages of postnatal life (aetiology). We tested whether the adult mice thereon obtained exhibited behavioral and neurochemical alterations isomorphic to symptoms of human depression.

Neonatal tryptophan depletion and corticosterone supplementation result in depressive-like abnormalities in adult male mice / Giovanni Laviola;Francesca Zoratto;Marco Fiore;Simone Macrì. - ELETTRONICO. - 15 (Supplement 1):(2012), pp. 188-189. (Intervento presentato al convegno 28th World Congress of the Collegium Internationale Neuro-Psychopharmacologicum (CINP) tenutosi a Stoccolma (Svezia) nel 3-7 giugno 2012).

Neonatal tryptophan depletion and corticosterone supplementation result in depressive-like abnormalities in adult male mice

ZORATTO, FRANCESCA;
2012

Abstract

Current rodent models of human depression suffer from limited construct and external validity whereby they disregard the nature-nurture interactive origin of the disease and are normally suited to inflexible conditions (e.g. single background strain). We developed a animal model reproducing several depressive-like features (symptoms) through the combination of reduced serotonin and environmental stress during the early stages of postnatal life (aetiology). We tested whether the adult mice thereon obtained exhibited behavioral and neurochemical alterations isomorphic to symptoms of human depression.
2012
The International Journal of Neuropsychopharmacology
28th World Congress of the Collegium Internationale Neuro-Psychopharmacologicum (CINP)
Stoccolma (Svezia)
Giovanni Laviola;Francesca Zoratto;Marco Fiore;Simone Macrì
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/806309
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