ere, we dissected the role of growth-associated protein 43 (GAP-43; also known as neuromodulin and B-50) in axonal structural plasticity by using, as a model, climbing fibers. Single axonal branches were dissected by laser axotomy, avoiding collateral damage to the adjacent dendrite and the formation of a persistent glial scar.
In vivo single branch axotomy induces GAP-43-dependent sprouting and synaptic remodeling in cerebellar cortex / A. L. Allegra Mascaro, P. Cesare, L. Sacconi, G. Grasselli, G. Mandolesi, B. Maco, G. W. Knott, L. Huang, V. De Paola, P. Strata, F. S. Pavone. - In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. - ISSN 0027-8424. - STAMPA. - 110:(2013), pp. 10824-10829. [10.1073/pnas.1219256110]
In vivo single branch axotomy induces GAP-43-dependent sprouting and synaptic remodeling in cerebellar cortex
ALLEGRA MASCARO, ANNA LETIZIA;SACCONI, LEONARDO;PAVONE, FRANCESCO SAVERIO
2013
Abstract
ere, we dissected the role of growth-associated protein 43 (GAP-43; also known as neuromodulin and B-50) in axonal structural plasticity by using, as a model, climbing fibers. Single axonal branches were dissected by laser axotomy, avoiding collateral damage to the adjacent dendrite and the formation of a persistent glial scar.
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