Growing evidence shows that GM1 ganglioside is involved in amyloid deposition and toxicity. By means of real-time single particle tracking, we show that amyloid oligomers and aggregates formed by Aβ1-42 and amylin, two peptides associated, respectively, with the development of Alzheimer's disease and type II diabetes, interact with GM1 and decrease dramatically its lateral diffusion on the plasma membrane of living neuroblastoma cells.
Partitioning and confinement of GM1 ganglioside induced by amyloid aggregates / Martino Calamai;Francesco S. Pavone. - In: FEBS LETTERS. - ISSN 0014-5793. - STAMPA. - 587:(2013), pp. 1385-1391. [10.1016/j.febslet.2013.03.014]
Partitioning and confinement of GM1 ganglioside induced by amyloid aggregates
PAVONE, FRANCESCO SAVERIO
2013
Abstract
Growing evidence shows that GM1 ganglioside is involved in amyloid deposition and toxicity. By means of real-time single particle tracking, we show that amyloid oligomers and aggregates formed by Aβ1-42 and amylin, two peptides associated, respectively, with the development of Alzheimer's disease and type II diabetes, interact with GM1 and decrease dramatically its lateral diffusion on the plasma membrane of living neuroblastoma cells.I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.