Heart failure (HF) is a complex clinical syndrome and numerous studies have aimed at defining the underlying pathophysiology using recent advances in the system biology approach as well as at discovering possible biomarkers to achieve a very early diagnosis of cardiac failure. An improved strategy may be represented by a global approach to HF, as suggested by several studies in which genomics, proteomics as well as transcriptomics have been used. Metabolomics may complete this -omic approach to HF and may provide a portrait of the metabolic phenomena that are involved in HF even in the early stages of the disease. Metabolomics considers the spectrum of the metabolites as a whole. The nuclear magnetic resonance (NMR) profile contains qualitative and quantitative information on the hundreds of different small molecules present in a biological sample.
Metabolomic fingerprint of heart failure in humans: A nuclear magnetic resonance spectroscopy analysis / Tenori L;Hu X;Pantaleo P;Alterini B;Castelli G;Olivotto I;Bertini I;Luchinat C;Gensini GF. - In: INTERNATIONAL JOURNAL OF CARDIOLOGY. - ISSN 0167-5273. - STAMPA. - 168:(2013), pp. 113-115. [10.1016/j.ijcard.2013.08.042]
Metabolomic fingerprint of heart failure in humans: A nuclear magnetic resonance spectroscopy analysis.
TENORI, LEONARDO;OLIVOTTO, IACOPO;BERTINI, IVANO;LUCHINAT, CLAUDIO;GENSINI, GIAN FRANCO
2013
Abstract
Heart failure (HF) is a complex clinical syndrome and numerous studies have aimed at defining the underlying pathophysiology using recent advances in the system biology approach as well as at discovering possible biomarkers to achieve a very early diagnosis of cardiac failure. An improved strategy may be represented by a global approach to HF, as suggested by several studies in which genomics, proteomics as well as transcriptomics have been used. Metabolomics may complete this -omic approach to HF and may provide a portrait of the metabolic phenomena that are involved in HF even in the early stages of the disease. Metabolomics considers the spectrum of the metabolites as a whole. The nuclear magnetic resonance (NMR) profile contains qualitative and quantitative information on the hundreds of different small molecules present in a biological sample.File | Dimensione | Formato | |
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