The E7 protein from human papillomavirus (HPV) plays a key role in oncogenesis; for this reason, it is a target of great biomedical interest. To date, no high resolution information is available for the full protein. We present here the NMR characterization of the entire E7 from HPV16, one of the most oncogenic variants of the virus. The protein is very heterogeneous in terms of structural and dynamic properties with a highly flexible N-terminal module and a more structured C terminus. This opens possibilities for studies of molecular-level interactions and post-translational modifications of the protein to unravel functional details that might be linked to its highly oncogenic potential.

The Heterogeneous Structural Behavior of E7 from HPV16 Revealed by NMR Spectroscopy / Eduardo O. Calçada; Isabella C. Felli; Tomas Hosek; Roberta Pierattelli. - In: CHEMBIOCHEM. - ISSN 1439-4227. - STAMPA. - 14:(2013), pp. 1876-1882. [10.1002/cbic.201300172]

The Heterogeneous Structural Behavior of E7 from HPV16 Revealed by NMR Spectroscopy

DE OLIVEIRA LOPES CALCADA, EDUARDO PAULO;FELLI, ISABELLA CATERINA;HOSEK, TOMAS;PIERATTELLI, ROBERTA
2013

Abstract

The E7 protein from human papillomavirus (HPV) plays a key role in oncogenesis; for this reason, it is a target of great biomedical interest. To date, no high resolution information is available for the full protein. We present here the NMR characterization of the entire E7 from HPV16, one of the most oncogenic variants of the virus. The protein is very heterogeneous in terms of structural and dynamic properties with a highly flexible N-terminal module and a more structured C terminus. This opens possibilities for studies of molecular-level interactions and post-translational modifications of the protein to unravel functional details that might be linked to its highly oncogenic potential.
2013
14
1876
1882
Eduardo O. Calçada; Isabella C. Felli; Tomas Hosek; Roberta Pierattelli
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/817120
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