Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) with a chronic course. Dysphagia represents one of the current challenges in clinical practice for the management of MS patients. Dysphagia starts to appear in mildly impaired MS subjects (EDSS 2-3) and becomes increasingly common in the most severely disabled subjects (EDSS 8-9). The aim of the present study was to evaluate the frequency and characteristics of patient-reported dysphagia in MS patients with a multicenter study using the recently developed DYMUS (DYsphagia in MUltiple Sclerosis) questionnaire.Data were collected in a multi-centre, cross-sectional study using a face-to-face structured questionnaire for clinical characteristics and the DYMUS questionnaire.1875 patients were interviewed. The current study has shown a correlation between patient-reported dysphagia and EDSS and disease course but not with age, gender and disease duration. Questionnaires were divided into "patient-reported dysphagia-yes" (587, 31.3\%) and "patient-reported dysphagia-no" (1288, 68.7\%). Compared with the patient-reported dysphagia-no group, patients in patient-reported dysphagia-yes group had higher EDSS score (mean EDSS 4.6 vs. 2.8; p<0.001) and had a longer disease duration (mean duration 13 years vs. 11 years; p<0.001), while there was no significant difference in gender (32.7\% vs. 30.5\% male and 67.3\% vs. 69.5\% female) and in age composition (46.18 vs. 42.05).This study represents the largest, multi-centre sample of MS patients evaluated for patient-reported dysphagia utilizing an ad-hoc questionnaire for this condition.

Prevalence of patient-reported dysphagia in multiple sclerosis patients: an Italian multicenter study (using the DYMUS questionnaire) / Solaro, C;Rezzani, C;Trabucco, E;Amato, MP;Zipoli, V;Portaccio, E;Giannini, M;Patti, F;D'Amico, E;Frau, J;Lorefice, L;Bonavita, S;Corte, MD;Grasso, MG;Finamore, L;Ghezzi, A;Annovazzi, P;Rottoli, M;Gasperini, C;Restivo, D;Maimone, D;Rossi, P;Stromillo, ML;Bergamaschi, R. - In: JOURNAL OF THE NEUROLOGICAL SCIENCES. - ISSN 0022-510X. - STAMPA. - 331:(2013), pp. 94-97. [10.1016/j.jns.2013.05.020]

Prevalence of patient-reported dysphagia in multiple sclerosis patients: an Italian multicenter study (using the DYMUS questionnaire).

AMATO, MARIA PIA;ZIPOLI, VALENTINA;PORTACCIO, EMILIO;GIANNINI, MARTA;
2013

Abstract

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) with a chronic course. Dysphagia represents one of the current challenges in clinical practice for the management of MS patients. Dysphagia starts to appear in mildly impaired MS subjects (EDSS 2-3) and becomes increasingly common in the most severely disabled subjects (EDSS 8-9). The aim of the present study was to evaluate the frequency and characteristics of patient-reported dysphagia in MS patients with a multicenter study using the recently developed DYMUS (DYsphagia in MUltiple Sclerosis) questionnaire.Data were collected in a multi-centre, cross-sectional study using a face-to-face structured questionnaire for clinical characteristics and the DYMUS questionnaire.1875 patients were interviewed. The current study has shown a correlation between patient-reported dysphagia and EDSS and disease course but not with age, gender and disease duration. Questionnaires were divided into "patient-reported dysphagia-yes" (587, 31.3\%) and "patient-reported dysphagia-no" (1288, 68.7\%). Compared with the patient-reported dysphagia-no group, patients in patient-reported dysphagia-yes group had higher EDSS score (mean EDSS 4.6 vs. 2.8; p<0.001) and had a longer disease duration (mean duration 13 years vs. 11 years; p<0.001), while there was no significant difference in gender (32.7\% vs. 30.5\% male and 67.3\% vs. 69.5\% female) and in age composition (46.18 vs. 42.05).This study represents the largest, multi-centre sample of MS patients evaluated for patient-reported dysphagia utilizing an ad-hoc questionnaire for this condition.
2013
331
94
97
Solaro, C;Rezzani, C;Trabucco, E;Amato, MP;Zipoli, V;Portaccio, E;Giannini, M;Patti, F;D'Amico, E;Frau, J;Lorefice, L;Bonavita, S;Corte, MD;Grasso, MG;Finamore, L;Ghezzi, A;Annovazzi, P;Rottoli, M;Gasperini, C;Restivo, D;Maimone, D;Rossi, P;Stromillo, ML;Bergamaschi, R
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/818485
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