Mitochondria carry maternally inherited genetic material, called the mitochondrial genome (mtDNA), which can be defined as the 25th human chromosome. The chromosome-centric Human Proteome Project (c-HPP) has initially focused its activities addressing the characterization and quantification of the nuclear encoded proteins. Following the last International HUPO Congress in Boston (September 2012) it was clear that however small the mitochondrial chromosome is, it plays an important role in many biological and physiopathological functions. Mutations in the mtDNA have been shown to be associated with dozens of unexplained disorders and the information contained in the mtDNA should be of major relevance to the understanding of many human diseases. Within this paper we describe the Italian initiative of the Human Proteome Project dedicated to mitochondria as part of both programs:
The mitochondrial Italian Human Proteome Project initiative (mt-HPP) / Andrea Urbani; Michele De Canio; Ferdinando Palmieri; Salvatore Sechi; Luca Bini; Massimo Castagnola; Mauro Fasano; Alessandra Modesti; Paola Roncada; Anna Maria Timperio; Luigi Bonizzi; Maurizio Brunori;l Francesca Cutruzzola'; Vito De Pinto; Carmine Di Ilio; Giorgio Federici; Franco Folli; Salvatore Foti; Cecilia Gelfi; Davide Lauro; Antonio Lucacchini; Fulvio Magni; Irene Messana; Pier Paolo Pandolfi; Sergio Papa; Piero Pucci; Paolo Sacchettaab and the Italian mt-HPP Study Group-Italian Proteomics Association (www.itpa.it). - In: MOLECULAR BIOSYSTEMS. - ISSN 1742-2051. - ELETTRONICO. - 8:(2013), pp. 0-0.
The mitochondrial Italian Human Proteome Project initiative (mt-HPP)
MODESTI, ALESSANDRA;
2013
Abstract
Mitochondria carry maternally inherited genetic material, called the mitochondrial genome (mtDNA), which can be defined as the 25th human chromosome. The chromosome-centric Human Proteome Project (c-HPP) has initially focused its activities addressing the characterization and quantification of the nuclear encoded proteins. Following the last International HUPO Congress in Boston (September 2012) it was clear that however small the mitochondrial chromosome is, it plays an important role in many biological and physiopathological functions. Mutations in the mtDNA have been shown to be associated with dozens of unexplained disorders and the information contained in the mtDNA should be of major relevance to the understanding of many human diseases. Within this paper we describe the Italian initiative of the Human Proteome Project dedicated to mitochondria as part of both programs:
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