Cancer cells undergo genetic changes allowing their adaptation to environmental changes, thereby obtaining an advantage during the long metastatic route, disseminated of several changes in the surrounding environment. In particular, plasticity in cell motility, mainly due to epigenetic regulation of cancer cells by environmental insults, engage adaptive strategies aimed essentially to survive in hostile milieu, thereby escaping adverse sites. This review is focused on tumor microenvironment as a collection of structural and cellular elements promoting plasticity and adaptive programs. We analyze the role of extracellular matrix stiffness, hypoxia, nutrient deprivation, acidity, as well as different cell populations of tumor microenvironment.

Microenvironment and tumor cell plasticity: An easy way out / Taddei ML; Giannoni E; Comito G; Chiarugi P.. - In: CANCER LETTERS. - ISSN 0304-3835. - STAMPA. - (2013), pp. ?-?.

Microenvironment and tumor cell plasticity: An easy way out.

TADDEI, MARIA LETIZIA;GIANNONI, ELISA;COMITO, GIUSEPPINA;CHIARUGI, PAOLA
2013

Abstract

Cancer cells undergo genetic changes allowing their adaptation to environmental changes, thereby obtaining an advantage during the long metastatic route, disseminated of several changes in the surrounding environment. In particular, plasticity in cell motility, mainly due to epigenetic regulation of cancer cells by environmental insults, engage adaptive strategies aimed essentially to survive in hostile milieu, thereby escaping adverse sites. This review is focused on tumor microenvironment as a collection of structural and cellular elements promoting plasticity and adaptive programs. We analyze the role of extracellular matrix stiffness, hypoxia, nutrient deprivation, acidity, as well as different cell populations of tumor microenvironment.
2013
?
?
Taddei ML; Giannoni E; Comito G; Chiarugi P.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/820691
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 202
  • ???jsp.display-item.citation.isi??? 186
social impact