Inflammation, which is now recognized as an hallmark of cancer, is intimately linked to the reactivity of stromal fibroblasts. Accumulating evidence indicate that cancer-associated fibroblasts not only drive the epithelial-mesenchymal transition and metabolically sustain the growth of cancer cells, but also engage in a reciprocal relationship with M2 macrophages that dramatically boost malignancy.
Cancer associated fibroblasts and macrophages: friendly conspirators for tumor malignancy / chiarugi p. - In: ONCOIMMUNOLOGY. - ISSN 2162-4011. - STAMPA. - (2013), pp. 25563-25565.
Cancer associated fibroblasts and macrophages: friendly conspirators for tumor malignancy
CHIARUGI, PAOLA
2013
Abstract
Inflammation, which is now recognized as an hallmark of cancer, is intimately linked to the reactivity of stromal fibroblasts. Accumulating evidence indicate that cancer-associated fibroblasts not only drive the epithelial-mesenchymal transition and metabolically sustain the growth of cancer cells, but also engage in a reciprocal relationship with M2 macrophages that dramatically boost malignancy.
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