Objectives/Hypothesis: To review toxicity and outcomes in patients with head and neck cancer treated with simultaneous integrated boost–intensity-modulated radiotherapy (SIB-IMRT). Study Design: Review of experience with the SIB-IMRT technique. Methods: Fifty patients were treated with the SIB-IMRT technique. Two possible schedules of radiation therapy (RT) were used: SIB 70 (70/60/54 in 33 fractions) and SIB 66 (66/60/54 in 33 fractions). Forty-one patients also received chemotherapy. Results: All but two patients completed treatment as prescribed. No G4 acute toxicity has been reported in our series. We did not observe any G3 to G4 chronic toxicity, apart from one case of cutaneous necrosis. After a median follow-up of 23.3 months (range, 1–60 months), 41 patients (82%) were alive and negative for disease, and one patient (2%) was alive with distant metastases. Eight patients (16%) died, seven because of progressive disease and one for other causes. Conclusions: SIB-IMRT is a highly effective and safe technique of RT in the treatment of head and neck cancer.
Simultaneous integrated boost-intensity-modulated radiotherapy in head and neck cancer / Davide Franceschini;Fabiola Paiar;Icro Meattini;Benedetta Agresti;Eleonora Monteleone Pasquetti;Daniela Greto;Pierluigi Bonomo;Livia Marrazzo;Marta Casati;Lorenzo Livi;Giampaolo Biti. - In: LARYNGOSCOPE. - ISSN 0023-852X. - STAMPA. - 123:(2013), pp. 97-103. [10.1002/lary.24257]
Simultaneous integrated boost-intensity-modulated radiotherapy in head and neck cancer
PAIAR, FABIOLA;MEATTINI, ICRO;MARRAZZO, LIVIA;LIVI, LORENZO;BITI, GIAMPAOLO
2013
Abstract
Objectives/Hypothesis: To review toxicity and outcomes in patients with head and neck cancer treated with simultaneous integrated boost–intensity-modulated radiotherapy (SIB-IMRT). Study Design: Review of experience with the SIB-IMRT technique. Methods: Fifty patients were treated with the SIB-IMRT technique. Two possible schedules of radiation therapy (RT) were used: SIB 70 (70/60/54 in 33 fractions) and SIB 66 (66/60/54 in 33 fractions). Forty-one patients also received chemotherapy. Results: All but two patients completed treatment as prescribed. No G4 acute toxicity has been reported in our series. We did not observe any G3 to G4 chronic toxicity, apart from one case of cutaneous necrosis. After a median follow-up of 23.3 months (range, 1–60 months), 41 patients (82%) were alive and negative for disease, and one patient (2%) was alive with distant metastases. Eight patients (16%) died, seven because of progressive disease and one for other causes. Conclusions: SIB-IMRT is a highly effective and safe technique of RT in the treatment of head and neck cancer.File | Dimensione | Formato | |
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