BACKGROUND: The use of adjuvant radiotherapy in ductal carcinoma in situ is accepted by most radiation oncologists worldwide; the role of a boost on the tumor bed is however more controversial. MATERIALS AND METHODS: We reviewed our Institute experience in DCIS treatment, focusing on main prognostic factors and impact of radiation boost on local relapse. A total of 389 patients treated between 1990 and 2007 were retrospectively analyzed. All patients received adjuvant radiotherapy after breast-conserving surgery for a median dose of 50 Gy; 190 patients (48.8%) received and additional radiation boost on the tumor bed. RESULTS: At a mean follow up of 7.7 years, we recorded 26 local recurrence (6.7%). Concerning local relapse-free survival, at Cox regression univariate analyses <1 mm surgical margins (p < 0.0001) and young age (p = 0.01) emerged as significant unfavorable prognostic factors. At multivariate analysis Cox regression model, surgical margins (p < 0.001) and radiation boost (p = 0.014) resulted as the significant independent predictors of recurrence. CONCLUSIONS: Our experience showed the negative prognostic impact of surgical margins <1 mm and the protective role of radiation boost on LR rate. Anyway, results from ongoing prospective Phase III studies are strongly necessary to better identify high-risk DCIS patients.

Role of radiotherapy boost in women with ductal carcinoma in situ: A single-center experience in a series of 389 patients / I. Meattini;L. Livi;D. Franceschini;C. Saieva;F. Meacci;L. Marrazzo;B. Bendinelli;V. Scotti;C. De Luca Cardillo;J. Nori;L. Sanchez;L. Orzalesi;P. Bonomo;D. Greto;M. Bucciolini;S. Bianchi;G. Biti. - In: EUROPEAN JOURNAL OF SURGICAL ONCOLOGY. - ISSN 0748-7983. - STAMPA. - 39:(2013), pp. 613-618. [10.1016/j.ejso.2013.03.002]

Role of radiotherapy boost in women with ductal carcinoma in situ: A single-center experience in a series of 389 patients

MEATTINI, ICRO;LIVI, LORENZO;MARRAZZO, LIVIA;DE LUCA CARDILLO, CARLA;ORZALESI, LORENZO;S. Bianchi;
2013

Abstract

BACKGROUND: The use of adjuvant radiotherapy in ductal carcinoma in situ is accepted by most radiation oncologists worldwide; the role of a boost on the tumor bed is however more controversial. MATERIALS AND METHODS: We reviewed our Institute experience in DCIS treatment, focusing on main prognostic factors and impact of radiation boost on local relapse. A total of 389 patients treated between 1990 and 2007 were retrospectively analyzed. All patients received adjuvant radiotherapy after breast-conserving surgery for a median dose of 50 Gy; 190 patients (48.8%) received and additional radiation boost on the tumor bed. RESULTS: At a mean follow up of 7.7 years, we recorded 26 local recurrence (6.7%). Concerning local relapse-free survival, at Cox regression univariate analyses <1 mm surgical margins (p < 0.0001) and young age (p = 0.01) emerged as significant unfavorable prognostic factors. At multivariate analysis Cox regression model, surgical margins (p < 0.001) and radiation boost (p = 0.014) resulted as the significant independent predictors of recurrence. CONCLUSIONS: Our experience showed the negative prognostic impact of surgical margins <1 mm and the protective role of radiation boost on LR rate. Anyway, results from ongoing prospective Phase III studies are strongly necessary to better identify high-risk DCIS patients.
2013
39
613
618
I. Meattini;L. Livi;D. Franceschini;C. Saieva;F. Meacci;L. Marrazzo;B. Bendinelli;V. Scotti;C. De Luca Cardillo;J. Nori;L. Sanchez;L. Orzalesi;P. Bonomo;D. Greto;M. Bucciolini;S. Bianchi;G. Biti
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/822175
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