The genotypic profile of rare amelanotic melanomas (AMs) has been poorly investigated, thus preventing either an accurate identification as a distinctive melanoma subtype or therapy stratification. Here, we investigated the presence of the BRAF mutation by real-time quantitative PCR and KIT mutations (exons 11 and 17) by sequencing analysis in 33 AMs.
BRAF and KIT somatic mutations are present in amelanotic melanoma / Massi D; Pinzani P; Simi L; Salvianti F; De Giorgi V; Pizzichetta MA; Mirri F; Steffan A; Orlando C; Santucci M; Canzonieri V.. - In: MELANOMA RESEARCH. - ISSN 0960-8931. - STAMPA. - (2013), pp. ---.
BRAF and KIT somatic mutations are present in amelanotic melanoma.
MASSI, DANIELA;PINZANI, PAMELA;Simi L;SALVIANTI, FRANCESCA;SANTUCCI, MARCO;
2013
Abstract
The genotypic profile of rare amelanotic melanomas (AMs) has been poorly investigated, thus preventing either an accurate identification as a distinctive melanoma subtype or therapy stratification. Here, we investigated the presence of the BRAF mutation by real-time quantitative PCR and KIT mutations (exons 11 and 17) by sequencing analysis in 33 AMs.
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