The reaction of Auoxo6,a dinucleargold(III) complex, with the model protein bovine pancreatic ribonuclease is here explored by X-ray diffraction and ESI mass spectrometry.Data provide clues on the processes of adduct formation and of enzyme inhibition and, inductively, on the likely mode of action of this metallodrug.
Interactions of Gold-based drugs with proteins: crystal structure of the adduct formed between Ribonuclease A and a cytotoxic gold(III) compound / Luigi Messori;Federica Scaletti;Lara Massai;Maria A. Cinellu;Irene Russo Krauss;Giovanna di Martino;Alessandro Vergara;Luigi Paduano;Antonello Merlino. - In: METALLOMICS. - ISSN 1756-5901. - STAMPA. - (2014), pp. 233-236. [10.1039/c3mt00265a]
Interactions of Gold-based drugs with proteins: crystal structure of the adduct formed between Ribonuclease A and a cytotoxic gold(III) compound
MESSORI, LUIGI;SCALETTI, FEDERICA;MASSAI, LARA;
2014
Abstract
The reaction of Auoxo6,a dinucleargold(III) complex, with the model protein bovine pancreatic ribonuclease is here explored by X-ray diffraction and ESI mass spectrometry.Data provide clues on the processes of adduct formation and of enzyme inhibition and, inductively, on the likely mode of action of this metallodrug.
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