Picking a fight with parasites! Trypanothione reductase (TR) is a validated drug target for the development of antileishmanial agents. A group of structurally diverse gold-containing compounds was evaluated in vitro for TR inhibition. A number of compounds exhibited potent activity and deserve further pharmacological evaluation.
Metal-Based Compounds as Prospective Antileishmanial Agents: Inhibition of Trypanothione Reductase by Selected Gold Complexes / Gianni Colotti;Andrea Ilari;Annarita Fiorillo;Paola Baiocco;Maria Agostina Cinellu;Laura Maiore;Federica Scaletti;Chiara Gabbiani;Luigi Messori. - In: CHEMMEDCHEM. - ISSN 1860-7179. - STAMPA. - 8:(2013), pp. 1634-1637. [10.1002/cmdc.201300276]
Metal-Based Compounds as Prospective Antileishmanial Agents: Inhibition of Trypanothione Reductase by Selected Gold Complexes
SCALETTI, FEDERICA;MESSORI, LUIGI
2013
Abstract
Picking a fight with parasites! Trypanothione reductase (TR) is a validated drug target for the development of antileishmanial agents. A group of structurally diverse gold-containing compounds was evaluated in vitro for TR inhibition. A number of compounds exhibited potent activity and deserve further pharmacological evaluation.
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