The interactions between a few representative gold-based drugs and hen egg white lysozyme were studied by X-ray crystallography. High resolution crystal structures solved for three metallodrug–protein adducts provide valuable insight into the molecular mechanism of these promising metal compounds and the inherent protein metalation processes.
The mode of action of anticancer gold-based drugs: a structural perspective / Luigi Messori;Federica Scaletti;Lara Massai;Maria A. Cinellu;Chiara Gabbiani;Alessandro Vergara;Antonello Merlino. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - STAMPA. - 49:(2013), pp. 10100-10102. [10.1039/c3cc46400h]
The mode of action of anticancer gold-based drugs: a structural perspective
MESSORI, LUIGI;SCALETTI, FEDERICA;MASSAI, LARA;
2013
Abstract
The interactions between a few representative gold-based drugs and hen egg white lysozyme were studied by X-ray crystallography. High resolution crystal structures solved for three metallodrug–protein adducts provide valuable insight into the molecular mechanism of these promising metal compounds and the inherent protein metalation processes.
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