The discovery of new compounds that are able to inhibit the growth of Burkholderia cenocepacia is of primary importance for cystic fibrosis patients. Here, the mechanism of resistance to a new pyridine derivative already shown to be effective against Mycobacterium tuberculosis and to have good activity toward B. cenocepacia was investigated. Increased expression of a resistance-nodulation-cell division (RND) efflux system was detected in the resistant mutants, thus confirming their important roles in B.cenocepacia antibiotic resistance.

Mechanism of resistance to an antitubercular 2-thiopyridine derivative that is also active against Burkholderia cenocepacia / V.C. Scoffone; F. Spadaro; C. Udine; V. Makarov; M. Fondi; R. Fani; E. De Rossi; G. Riccardi; S. Buroni. - In: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. - ISSN 0066-4804. - STAMPA. - 58:(2014), pp. 2415-2417.

Mechanism of resistance to an antitubercular 2-thiopyridine derivative that is also active against Burkholderia cenocepacia

FONDI, MARCO;FANI, RENATO;
2014

Abstract

The discovery of new compounds that are able to inhibit the growth of Burkholderia cenocepacia is of primary importance for cystic fibrosis patients. Here, the mechanism of resistance to a new pyridine derivative already shown to be effective against Mycobacterium tuberculosis and to have good activity toward B. cenocepacia was investigated. Increased expression of a resistance-nodulation-cell division (RND) efflux system was detected in the resistant mutants, thus confirming their important roles in B.cenocepacia antibiotic resistance.
2014
58
2415
2417
V.C. Scoffone; F. Spadaro; C. Udine; V. Makarov; M. Fondi; R. Fani; E. De Rossi; G. Riccardi; S. Buroni
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/829097
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