Acute generalized exanthematous pustolosis (AGEP) is a rare adverse drug reaction, frequently due to β- Lactams, characterized by skin eruption, nonfollicular sterile pustules, fever and neutrophilia with neutrophilic and, possibly, eosinophilic infiltrates. To disclose the possible involvement of IL-17 in AGEP, we investigated the functional phenotype of hapten-specific T cell clones (TCCs) derived from the peripheral blood of a patient with history of β-Lactaminduced AGEP.
Hapten-Specific TH17 Cells in the Peripheral Blood of β-Lactam-Induced AGEP / Fili L; Cardilicchia E; Severino MG; Testi S; Matucci A; Vultaggio A; Paglierani M; Massi D; Maggi E; Parronchi P. - In: ALLERGOLOGY INTERNATIONAL. - ISSN 1323-8930. - STAMPA. - 63(1):(2014), pp. 129-131. [10.2332/allergolint.13-LE-0582]
Hapten-Specific TH17 Cells in the Peripheral Blood of β-Lactam-Induced AGEP.
FILI', LUCIA;CARDILICCHIA, ELISA;MATUCCI, ANDREA;VULTAGGIO, ALESSANDRA;PAGLIERANI, MILENA;MASSI, DANIELA;MAGGI, ENRICO;PARRONCHI, PAOLA
2014
Abstract
Acute generalized exanthematous pustolosis (AGEP) is a rare adverse drug reaction, frequently due to β- Lactams, characterized by skin eruption, nonfollicular sterile pustules, fever and neutrophilia with neutrophilic and, possibly, eosinophilic infiltrates. To disclose the possible involvement of IL-17 in AGEP, we investigated the functional phenotype of hapten-specific T cell clones (TCCs) derived from the peripheral blood of a patient with history of β-Lactaminduced AGEP.
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