Cu(I)-catalyzed Azide-Alkyne Cycloaddition (CuAAC) is often utilized in medicinal chemistry to make the triazole moiety as it acts as a non-classical bioisostere of the peptide bond. This useful technique can also be applied in the fragment-based assembly of molecular libraries for high-throughput screening. This minireview outlines the application of click-chemistry in the synthesis of enzyme inhibitors with the triazole moiety.

Use of Click-Chemistry in the Development of Peptidomimetic Enzyme Inhibitors / P. Fabbrizzi;G. Menchi;A. Guarna;A. Trabocchi. - In: CURRENT MEDICINAL CHEMISTRY. - ISSN 0929-8673. - STAMPA. - 21:(2014), pp. 1467-1477. [10.2174/0929867321666131218093611]

Use of Click-Chemistry in the Development of Peptidomimetic Enzyme Inhibitors

FABBRIZZI, PIERANGELO;MENCHI, GLORIA;GUARNA, ANTONIO;TRABOCCHI, ANDREA
2014

Abstract

Cu(I)-catalyzed Azide-Alkyne Cycloaddition (CuAAC) is often utilized in medicinal chemistry to make the triazole moiety as it acts as a non-classical bioisostere of the peptide bond. This useful technique can also be applied in the fragment-based assembly of molecular libraries for high-throughput screening. This minireview outlines the application of click-chemistry in the synthesis of enzyme inhibitors with the triazole moiety.
2014
21
1467
1477
P. Fabbrizzi;G. Menchi;A. Guarna;A. Trabocchi
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/846719
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