Angiotensin converting enzyme (ACE) is a circulating enzyme that is responsible for the conversion of Angiotensin I (inactive) to Angiotensin II (active), peptide that plays an important role in the homeostatic control of arterial pressure, tissue perfusion and extracellular volume (Renin-Angiotensin-Aldosterone System, RAAS) . In 1990 Rigat and collegues identified a polymorphism characterized by the presence (Insertion, I) or absence (Deletion, D) of a 287 bp Alu sequence in intron 16 of the ACE gene (rs4646994). It’s a common genetic polymorphism and shows marked ethnic differences in its distribution. PubMed database was consulted to find scientific papers in which were reported data about the I/D allelic frequencies in different population of the world (case-control studies). Only data from controls were included in the present study. Data on the global distribution of I/D ACE gene allele frequencies were compiled from 186 studies. We considered only data related to ethnic groups historically located in a given geographical area. The present work is based on the I/D ACE genotypization of 55.629 individuals belonging to 86 different populations of the world. The results of the analysis reveal a “longitude effect”: the I allele frequency is very low in East Africa and Middle East and tend to increase with longitude, showing the highest values in those populations that had faced the longest migrations during the Paleolithic era.
I/D ACE gene polymorphism distribution in the world and human prehistoric migrations / Marianna Rinaldi. - In: JOURNAL OF BIOLOGICAL RESEARCH. - ISSN 1826-8838. - STAMPA. - (2011), pp. 168-169. (Intervento presentato al convegno XIX Congress of Associazione Antropologica Italiana, Turin, 21-24 September 2011. "1961-2011: 50 years of congresses: past, present and future of anthropology).
I/D ACE gene polymorphism distribution in the world and human prehistoric migrations.
RINALDI, MARIANNA
2011
Abstract
Angiotensin converting enzyme (ACE) is a circulating enzyme that is responsible for the conversion of Angiotensin I (inactive) to Angiotensin II (active), peptide that plays an important role in the homeostatic control of arterial pressure, tissue perfusion and extracellular volume (Renin-Angiotensin-Aldosterone System, RAAS) . In 1990 Rigat and collegues identified a polymorphism characterized by the presence (Insertion, I) or absence (Deletion, D) of a 287 bp Alu sequence in intron 16 of the ACE gene (rs4646994). It’s a common genetic polymorphism and shows marked ethnic differences in its distribution. PubMed database was consulted to find scientific papers in which were reported data about the I/D allelic frequencies in different population of the world (case-control studies). Only data from controls were included in the present study. Data on the global distribution of I/D ACE gene allele frequencies were compiled from 186 studies. We considered only data related to ethnic groups historically located in a given geographical area. The present work is based on the I/D ACE genotypization of 55.629 individuals belonging to 86 different populations of the world. The results of the analysis reveal a “longitude effect”: the I allele frequency is very low in East Africa and Middle East and tend to increase with longitude, showing the highest values in those populations that had faced the longest migrations during the Paleolithic era.File | Dimensione | Formato | |
---|---|---|---|
4097-14478-1-SM.pdf
accesso aperto
Tipologia:
Pdf editoriale (Version of record)
Licenza:
Open Access
Dimensione
440.25 kB
Formato
Adobe PDF
|
440.25 kB | Adobe PDF |
I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.