In historical times epidemics and pandemics killed large proportions of the European population, with likely consequences for the human genome as a result of positive selection acting on protective alleles. Pathophysiological evidence has suggested, for example, that cystic fibrosis mutations may confer resistance to cholera or other chloride-secreting diarrhoeas, whereas a high incidence of the CCR5-Delta32 mutation, which nowadays plays a substantial role in immunity against HIV-I infection, has been proposed to have provided some immunity against plague (...............)
"Evolutionary consequences of the past pandemics" / Barbara Bramanti; Stephanie Hänsch; Magdalena Bogus; Anja Meister; Claudio Ottoni; Antonella Lannino; Joachim Burger; Mark G. Thomas. - ELETTRONICO. - (2013), pp. 1-2. (Intervento presentato al convegno Ancient DNA: applications in human evolutionary history tenutosi a London nel 20-21 Novembre 2013).
"Evolutionary consequences of the past pandemics"
BRAMANTI, BARBARA;LANNINO, ANTONELLA;
2013
Abstract
In historical times epidemics and pandemics killed large proportions of the European population, with likely consequences for the human genome as a result of positive selection acting on protective alleles. Pathophysiological evidence has suggested, for example, that cystic fibrosis mutations may confer resistance to cholera or other chloride-secreting diarrhoeas, whereas a high incidence of the CCR5-Delta32 mutation, which nowadays plays a substantial role in immunity against HIV-I infection, has been proposed to have provided some immunity against plague (...............)
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