The performance of some amorphous cyclodextrin (CD) derivatives in terms of complexing, solubilizing and amorphizing power towards clonazepam was carefully evaluated and compared with that of natural CDs. The role of CD cavity size, amorphous or crystalline nature, and presence and type of substituents on its ability in producing effective interactions with the drug has been investigated
Physico-chemical characterization in solution and in the solid state of clonazepam complexes with native and chemically-modified cyclodextrins / Natascia Mennini; Marco Bragagni; Francesca Maestrelli; Paola Mura. - In: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. - ISSN 0731-7085. - STAMPA. - 89:(2014), pp. 142-149. [10.1016/j.jpba.2013.11.009]
Physico-chemical characterization in solution and in the solid state of clonazepam complexes with native and chemically-modified cyclodextrins
MENNINI, NATASCIA;BRAGAGNI, MARCO;MAESTRELLI, FRANCESCA;MURA, PAOLA ANGELA
2014
Abstract
The performance of some amorphous cyclodextrin (CD) derivatives in terms of complexing, solubilizing and amorphizing power towards clonazepam was carefully evaluated and compared with that of natural CDs. The role of CD cavity size, amorphous or crystalline nature, and presence and type of substituents on its ability in producing effective interactions with the drug has been investigated
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