The aim of this work was to investigate in-depth interactions of econazole nitrate (ECN), a very poorly water-soluble antifungal agent, with different β-cyclodextrin (βCD) derivatives, and to evaluate the potential synergistic effect of suitable third compounds (l-amino acids, citric acid, hydrophilic polymers).
Comparative analysis of binary and ternary cyclodextrin complexes with econazole nitrate in solution and in solid state / Mario Jug; Natascia Mennini; Katalin Kover; Paola Mura. - In: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. - ISSN 0731-7085. - STAMPA. - 91:(2014), pp. 81-91. [10.1016/j.jpba.2013.12.029]
Comparative analysis of binary and ternary cyclodextrin complexes with econazole nitrate in solution and in solid state
JUG, MARIO;MENNINI, NATASCIA;MURA, PAOLA ANGELA
2014
Abstract
The aim of this work was to investigate in-depth interactions of econazole nitrate (ECN), a very poorly water-soluble antifungal agent, with different β-cyclodextrin (βCD) derivatives, and to evaluate the potential synergistic effect of suitable third compounds (l-amino acids, citric acid, hydrophilic polymers).
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