Infants born to epileptic women treated with antiepileptic drugs (AEDs) have an increased risk of major congenital malformations (MCMs). In order to determine the role of maternal epilepsy we conducted a prospective cohort study on three cohorts of pregnant women: (i) 385 epileptic women treated with AEDs, (ii) 310 non-epileptic women treated with AEDs, (iii) 867 healthy women not exposed to AEDs (control group). The rate of MCMs in the epileptic group (7.7%) was not statistically higher than in the non-epileptic one (3.9%) (p = 0.068). The rate in the first group was higher compared to the control group (p = 0.001), while the rate in the second one was not (p = 0.534). Our data confirm that AEDs therapy is the main cause of the increased risk of malformations in the offspring of epileptic women; however a teratogenic role of the maternal epilepsy itself cannot be excluded.

Pregnancy outcome in women exposed to antiepileptic drugs: Teratogenic role of maternal epilepsy and its pharmacologic treatment / Matteo Cassina; Arianna Dilaghi; Elena Di Gianantonio; Elena Cesari; Marco De Santis; Guido Mannaioni; Alessandra Pistelli; Maurizio Clementi. - In: REPRODUCTIVE TOXICOLOGY. - ISSN 0890-6238. - STAMPA. - 39:(2013), pp. 50-57. [10.1016/j.reprotox.2013.04.002]

Pregnancy outcome in women exposed to antiepileptic drugs: Teratogenic role of maternal epilepsy and its pharmacologic treatment

DILAGHI, ARIANNA;MANNAIONI, GUIDO;PISTELLI, ALESSANDRA;
2013

Abstract

Infants born to epileptic women treated with antiepileptic drugs (AEDs) have an increased risk of major congenital malformations (MCMs). In order to determine the role of maternal epilepsy we conducted a prospective cohort study on three cohorts of pregnant women: (i) 385 epileptic women treated with AEDs, (ii) 310 non-epileptic women treated with AEDs, (iii) 867 healthy women not exposed to AEDs (control group). The rate of MCMs in the epileptic group (7.7%) was not statistically higher than in the non-epileptic one (3.9%) (p = 0.068). The rate in the first group was higher compared to the control group (p = 0.001), while the rate in the second one was not (p = 0.534). Our data confirm that AEDs therapy is the main cause of the increased risk of malformations in the offspring of epileptic women; however a teratogenic role of the maternal epilepsy itself cannot be excluded.
2013
39
50
57
Matteo Cassina; Arianna Dilaghi; Elena Di Gianantonio; Elena Cesari; Marco De Santis; Guido Mannaioni; Alessandra Pistelli; Maurizio Clementi
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/864508
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