A subset of sinonasal adenocarcinomas shows overexpression of EGFR, while activating mutations of the signaling cascade downstream of EGFR are rare, suggesting that these tumors could be good candidates for anti-EGFR therapies.
Low Prevalence of K-RAS, EGF-R and BRAF Mutations in Sinonasal Adenocarcinomas. Implications for Anti-EGFR Treatments / Franchi A;Innocenti DR;Palomba A;Miligi L;Paiar F;Franzese C;Santucci M. - In: PATHOLOGY ONCOLOGY RESEARCH. - ISSN 1219-4956. - STAMPA. - (2013). [10.1007/s12253-013-9730-1]
Low Prevalence of K-RAS, EGF-R and BRAF Mutations in Sinonasal Adenocarcinomas. Implications for Anti-EGFR Treatments.
FRANCHI, ALESSANDRO;SANTUCCI, MARCO
2013
Abstract
A subset of sinonasal adenocarcinomas shows overexpression of EGFR, while activating mutations of the signaling cascade downstream of EGFR are rare, suggesting that these tumors could be good candidates for anti-EGFR therapies.
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