A small set of N-bridged 1-deoxynojirimycin dimers has been synthesized and evaluated as potential inhibitors of insect trehalase from midge larvae of Chironomus riparius, porcine trehalase as the mammalian counterpart and a-amylase from human saliva. All the tested compounds (2–4) proved to be active (micromolar range activity) against insect trehalase, showing selectivity toward the insect glycosidase. No activity was observed against a-amylase.
N-Bridged 1-deoxynojirimycin dimers as selective insect trehalase inhibitors / Laura Cipolla; Antonella Sgambato; Matilde Forcella; Paola Fusi; Paolo Parenti; Francesca Cardona; Davide Bini. - In: CARBOHYDRATE RESEARCH. - ISSN 0008-6215. - STAMPA. - 389:(2014), pp. 46-49. [10.1016/j.carres.2013.12.025]
N-Bridged 1-deoxynojirimycin dimers as selective insect trehalase inhibitors
CARDONA, FRANCESCA;
2014
Abstract
A small set of N-bridged 1-deoxynojirimycin dimers has been synthesized and evaluated as potential inhibitors of insect trehalase from midge larvae of Chironomus riparius, porcine trehalase as the mammalian counterpart and a-amylase from human saliva. All the tested compounds (2–4) proved to be active (micromolar range activity) against insect trehalase, showing selectivity toward the insect glycosidase. No activity was observed against a-amylase.File | Dimensione | Formato | |
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