The possible relation between ear lobe crease (ELC) and coronary artery disease (CAD) was described for the first time by Frank in 1973 in a letter to the editor of the New England Journal of Medicine [1]. The author observed that 19 out of 20 patients with ELC had 1 or more risk factors for CAD, and he suggested that the presumptive relation should have been tested.
Ear lobe crease as a marker of coronary artery disease: a meta-analysis / Lucenteforte E;Romoli M;Zagli G;Gensini GF;Mugelli A;Vannacci A. - In: INTERNATIONAL JOURNAL OF CARDIOLOGY. - ISSN 0167-5273. - STAMPA. - 175:(2014), pp. 171-175. [10.1016/j.ijcard.2014.04.025]
Ear lobe crease as a marker of coronary artery disease: a meta-analysis.
LUCENTEFORTE, ERSILIA;ZAGLI, GIOVANNI;GENSINI, GIAN FRANCO;MUGELLI, ALESSANDRO;VANNACCI, ALFREDO
2014
Abstract
The possible relation between ear lobe crease (ELC) and coronary artery disease (CAD) was described for the first time by Frank in 1973 in a letter to the editor of the New England Journal of Medicine [1]. The author observed that 19 out of 20 patients with ELC had 1 or more risk factors for CAD, and he suggested that the presumptive relation should have been tested.
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