We show for the first time that 1,2-dilauroyl-sn-glycero-3-phosphatidyladenosine nucleolipid surface complexes with cationic poly(amidoamine) dendrimers can be used to selectively bind DNA including oligonucleotides. This molecular recognition has high potential for applications involving biomedical and bioanalytic devices as well as drug delivery systems based on nucleic acids.
Molecular recognition of nucleic acids by nucleolipid/dendrimer surface complexes / Marianna Yanez Arteta;Debora Berti;Costanza Montis;Richard A. Campbell;Luke A. Clifton;Maximilian W. A. Skoda;Olaf Soltwedel;Piero Baglioni;Tommy Nylander. - In: SOFT MATTER. - ISSN 1744-683X. - STAMPA. - 10:(2014), pp. 8401-8405. [10.1039/C4SM01733A]
Molecular recognition of nucleic acids by nucleolipid/dendrimer surface complexes
BERTI, DEBORA;MONTIS, COSTANZA;BAGLIONI, PIERO;
2014
Abstract
We show for the first time that 1,2-dilauroyl-sn-glycero-3-phosphatidyladenosine nucleolipid surface complexes with cationic poly(amidoamine) dendrimers can be used to selectively bind DNA including oligonucleotides. This molecular recognition has high potential for applications involving biomedical and bioanalytic devices as well as drug delivery systems based on nucleic acids.I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.