Aims and background. To report the clinical outcome of linac-based or robotic, image-guided stereotactic body radiotherapy in patients affected by abdominal lymph node metastases from different primary cancers. Methods and methods. Twenty-six patients with 32 abdominal lymph node metastases were consecutively treated at the University of Florence between April 2011 and May 2012. The mean follow-up was 4.6 months (SD, 3.9; range, 0.3-13). The dose prescription ranged between 24 Gy and 36 Gy delivered in 1-5 fractions. Results. In terms of local control, complete response to stereotactic body radiotherapy was obtained in 18 cases (66.7%), partial response in 7 (25.9%), and stable disease in 2 (7.4%). At the Cox univariate regression analysis, an increased risk of partial response or absence of local response to radiotherapy was found for subjects of the female sex (P = 0.036), age less than 50 years (P = 0.022), primary tumor of the genital tract (P = 0.007), and previous chemotherapy (P = 0.057). An excellent local control rate (90.9%) was obtained in patients affected by abdominal lymph node metastases of prostatic origin. Conclusions. Stereotactic body radiotherapy for abdominal lymph node metastases is a safe and effective treatment in terms of high rates of local control, especially in a subset of patients affected by prostate cancer.

Clinical outcome of stereotactic body radiotherapy for abdominal lymph node metastases / Bonomo, P; Cipressi, S; Saieva, C; Greto, D; Masi, L; Paiar, F; Di Cataldo, V; Meattini, I; Cecchini, S; Mangoni, M; Doro, R; Iermano, C; Bonucci, I; Livi, L; Biti, G. - In: TUMORI. - ISSN 0300-8916. - STAMPA. - 99:(2013), pp. 611-616. [10.1700/1377.15311]

Clinical outcome of stereotactic body radiotherapy for abdominal lymph node metastases.

BONOMO, PIERLUIGI;CIPRESSI, SAMANTHA;GRETO, DANIELA;PAIAR, FABIOLA;DI CATALDO, VANESSA;MEATTINI, ICRO;CECCHINI, SARA;MANGONI, MONICA;IERMANO, CARMINE;LIVI, LORENZO;BITI, GIAMPAOLO
2013

Abstract

Aims and background. To report the clinical outcome of linac-based or robotic, image-guided stereotactic body radiotherapy in patients affected by abdominal lymph node metastases from different primary cancers. Methods and methods. Twenty-six patients with 32 abdominal lymph node metastases were consecutively treated at the University of Florence between April 2011 and May 2012. The mean follow-up was 4.6 months (SD, 3.9; range, 0.3-13). The dose prescription ranged between 24 Gy and 36 Gy delivered in 1-5 fractions. Results. In terms of local control, complete response to stereotactic body radiotherapy was obtained in 18 cases (66.7%), partial response in 7 (25.9%), and stable disease in 2 (7.4%). At the Cox univariate regression analysis, an increased risk of partial response or absence of local response to radiotherapy was found for subjects of the female sex (P = 0.036), age less than 50 years (P = 0.022), primary tumor of the genital tract (P = 0.007), and previous chemotherapy (P = 0.057). An excellent local control rate (90.9%) was obtained in patients affected by abdominal lymph node metastases of prostatic origin. Conclusions. Stereotactic body radiotherapy for abdominal lymph node metastases is a safe and effective treatment in terms of high rates of local control, especially in a subset of patients affected by prostate cancer.
2013
99
611
616
Bonomo, P; Cipressi, S; Saieva, C; Greto, D; Masi, L; Paiar, F; Di Cataldo, V; Meattini, I; Cecchini, S; Mangoni, M; Doro, R; Iermano, C; Bonucci, I; ...espandi
File in questo prodotto:
File Dimensione Formato  
Bonomo 2013 Tumori_abdominal lymph node.pdf

Accesso chiuso

Descrizione: Paper
Tipologia: Pdf editoriale (Version of record)
Licenza: Tutti i diritti riservati
Dimensione 109.25 kB
Formato Adobe PDF
109.25 kB Adobe PDF   Richiedi una copia

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/928735
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 18
  • ???jsp.display-item.citation.isi??? 19
social impact