The N,N’-bis[(3-hydroxy-4-pyron-2-yl)methyl]-N,N’- dimethylethylendiamine (Malten=L) forms the highly stable [CuH2L] species in water, in which the converging maltol oxygen atoms form an electron-rich area able to host hard metal ions. When considering the alkaline earth series (AE), the [Cu(H2L)] species binds all metal ions, with the exception of Mg2+, exhibiting the relevant property to discriminate Ca2+ versus Mg2+ at physiological pH 7.4; the binding of the AE metal is visible to the naked eye. The stability constant values of the trinuclear [AE{Cu(H2L)}2]2+ species formed reach the maximum for Ca2+ (log K=7.7). Ca2+ also forms a tetranuclear [Ca{Cu(H2L)}]2 4+ species at a high Ca2+ concentration. Tri- and tetranuclear calcium complexes show blue- and pink-colored crystals, respectively. [Cu(H2L)] is the most active species in inducing DNA alterations. The DNA damages are compatible with its hydrolytic cleavages.

A Preorganized Metalloreceptor for Alkaline Earth Ions Showing Calcium Versus Magnesium Selectivity in Water: Biological Activity of Selected Metal Complexes / Stefano Amatori; Gianluca Ambrosi; Mirco Fanelli; Mauro Formica; Vieri Fusi; Luca Giorgi;Eleonora Macedi; Mauro Micheloni; Paola Paoli; Patrizia Rossi. - In: CHEMISTRY-A EUROPEAN JOURNAL. - ISSN 0947-6539. - STAMPA. - 20:(2014), pp. 11048-11057. [10.1002/chem.201403084]

A Preorganized Metalloreceptor for Alkaline Earth Ions Showing Calcium Versus Magnesium Selectivity in Water: Biological Activity of Selected Metal Complexes

PAOLI, PAOLA;ROSSI, PATRIZIA
2014

Abstract

The N,N’-bis[(3-hydroxy-4-pyron-2-yl)methyl]-N,N’- dimethylethylendiamine (Malten=L) forms the highly stable [CuH2L] species in water, in which the converging maltol oxygen atoms form an electron-rich area able to host hard metal ions. When considering the alkaline earth series (AE), the [Cu(H2L)] species binds all metal ions, with the exception of Mg2+, exhibiting the relevant property to discriminate Ca2+ versus Mg2+ at physiological pH 7.4; the binding of the AE metal is visible to the naked eye. The stability constant values of the trinuclear [AE{Cu(H2L)}2]2+ species formed reach the maximum for Ca2+ (log K=7.7). Ca2+ also forms a tetranuclear [Ca{Cu(H2L)}]2 4+ species at a high Ca2+ concentration. Tri- and tetranuclear calcium complexes show blue- and pink-colored crystals, respectively. [Cu(H2L)] is the most active species in inducing DNA alterations. The DNA damages are compatible with its hydrolytic cleavages.
2014
20
11048
11057
Stefano Amatori; Gianluca Ambrosi; Mirco Fanelli; Mauro Formica; Vieri Fusi; Luca Giorgi;Eleonora Macedi; Mauro Micheloni; Paola Paoli; Patrizia Rossi
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/944930
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