Introduction: After laparoscopic sleeve gastrectomy (LSG) metabolic syndrome improves dramatically, in particular with a high rate of type 2 diabetes remission. Circulating branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) were recently related to insulin resistance and diabetes. We applied metabolomic profiling to understand the mechanisms of this metabolic response after SLG. Method: Circulating amino acids (AAs) were measured in plasma from 20 subjects by nuclear magnetic resonance (NRM) metabolomics analysis before and at 1- and 6-month postoperatively after LSG. Results: Circulating AAs and BCAAs significantly decreased after LSG at 1- and in particular at 6-month post-op (Table, data are presented as median±median absolute deviation). Metabolites derived from BCAAs oxidation also decreased after LSG. Conclusion: LSG demonstrated a significant modification of circulating AAs metabolic profile in particular those AAs related to obesity, insulin sensitivity and metabolic syndrome, as BCAAs. These data suggest that the specific action determined by LSG on glucose homeostasis occurs by mechanisms other than weight loss.
Circulating Amino Acids Profile Before and After Sleeve Gastrectomy: A Metabolomic Study / G. Casella;E. Cavarretta;L. Tenori;G. Frati;C. Luchinat;L. Banci;A. Redler;D. Giannotti;G. Condorelli;N. Basso. - In: OBESITY SURGERY. - ISSN 0960-8923. - STAMPA. - 23:(2013), pp. 1048-1049. [10.1007/s11695-013-0986-z]
Circulating Amino Acids Profile Before and After Sleeve Gastrectomy: A Metabolomic Study
TENORI, LEONARDO;LUCHINAT, CLAUDIO;BANCI, LUCIA;
2013
Abstract
Introduction: After laparoscopic sleeve gastrectomy (LSG) metabolic syndrome improves dramatically, in particular with a high rate of type 2 diabetes remission. Circulating branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) were recently related to insulin resistance and diabetes. We applied metabolomic profiling to understand the mechanisms of this metabolic response after SLG. Method: Circulating amino acids (AAs) were measured in plasma from 20 subjects by nuclear magnetic resonance (NRM) metabolomics analysis before and at 1- and 6-month postoperatively after LSG. Results: Circulating AAs and BCAAs significantly decreased after LSG at 1- and in particular at 6-month post-op (Table, data are presented as median±median absolute deviation). Metabolites derived from BCAAs oxidation also decreased after LSG. Conclusion: LSG demonstrated a significant modification of circulating AAs metabolic profile in particular those AAs related to obesity, insulin sensitivity and metabolic syndrome, as BCAAs. These data suggest that the specific action determined by LSG on glucose homeostasis occurs by mechanisms other than weight loss.
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