Previous studies have suggested a pathogenetic role of autoantibodies (Abs) against ATP synthase (ATPs) in patients with Alzheimer's disease (AD). Using a mouse model, we found that intracerebroventricular administration of anti-ATPs-Abs, purified from AD patients, leads to poor cognitive performance and pronounced cell damage in the hippocampus, a brain region specifically involved in learning and memory processes, which is severely affected in AD. Our results are suggestive of a role of anti-ATPs-Abs in the onset and progression of AD and also provide a fruitful model for the study of memory disturbances in neurodegenerative diseases.
Anti-ATP Synthase Autoantibodies Induce Neuronal Death by Apoptosis and Impair Cognitive Performance in C57BL/6J Mice / Berry A; Vacirca D; Capoccia S; Bellisario V; Malorni W; Ortona E; Cirulli F. - In: JOURNAL OF ALZHEIMER'S DISEASE. - ISSN 1875-8908. - ELETTRONICO. - (2013), pp. 317-321. [10.3233/JAD-2012-121312]
Anti-ATP Synthase Autoantibodies Induce Neuronal Death by Apoptosis and Impair Cognitive Performance in C57BL/6J Mice
CAPOCCIA, SARA;
2013
Abstract
Previous studies have suggested a pathogenetic role of autoantibodies (Abs) against ATP synthase (ATPs) in patients with Alzheimer's disease (AD). Using a mouse model, we found that intracerebroventricular administration of anti-ATPs-Abs, purified from AD patients, leads to poor cognitive performance and pronounced cell damage in the hippocampus, a brain region specifically involved in learning and memory processes, which is severely affected in AD. Our results are suggestive of a role of anti-ATPs-Abs in the onset and progression of AD and also provide a fruitful model for the study of memory disturbances in neurodegenerative diseases.
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